| Date | Competition | Outcome | Home team | Score/Time | Visiting Team | ||
|---|---|---|---|---|---|---|---|
| 05/20/2012 | Liga MX | W |
Santos Laguna | 2 - 1 | Monterrey | View events | More info |
| 07/21/2012 | Liga MX | W |
Santos Laguna | 2 - 1 | San Luis | View events | More info |
| 07/29/2012 | Liga MX | W |
Guadalajara | 0 - 1 | Santos Laguna | View events | More info |
| 08/03/2012 | Liga MX | D |
Santos Laguna | 2 - 2 | Puebla | View events | More info |
| 08/05/2012 | Club Fr… | L |
Santos Laguna | 1 - 2 | Real Madrid | More info | |
| 08/10/2012 | Liga MX | L |
León | 3 - 0 | Santos Laguna | View events | More info |
| 08/18/2012 | Liga MX | L |
Santos Laguna | 1 - 2 | Pumas | View events | More info |
| 08/21/2012 | Champio… | W |
Santos Laguna | 5 - 0 | Águila | View events | More info |
| 08/25/2012 | Liga MX | D |
Pachuca | 0 - 0 | Santos Laguna | More info | |
| 08/28/2012 | Champio… | W |
Toronto | 1 - 3 | Santos Laguna | View events | More info |
| 09/01/2012 | Liga MX | W |
Santos Laguna | 3 - 1 | Tigres UANL | View events | More info |
| 09/15/2012 | Liga MX | L |
América | 2 - 0 | Santos Laguna | View events | More info |
| 09/19/2012 | Champio… | W |
Águila | 0 - 4 | Santos Laguna | View events | More info |
| 09/22/2012 | Liga MX | D |
Santos Laguna | 0 - 0 | Jaguares | More info | |
| 09/30/2012 | Liga MX | W |
Atlante | 1 - 3 | Santos Laguna | View events | More info |
| 10/03/2012 | Liga MX | W |
Santos Laguna | 2 - 1 | Atlas | View events | More info |
| 10/06/2012 | Liga MX | D |
Querétaro | 1 - 1 | Santos Laguna | View events | More info |
| 10/13/2012 | Liga MX | D |
Santos Laguna | 2 - 2 | Tijuana | View events | More info |
| 10/21/2012 | Liga MX | L |
Toluca | 4 - 1 | Santos Laguna | View events | More info |
| 10/24/2012 | Champio… | W |
Santos Laguna | 1 - 0 | Toronto | View events | More info |
| 10/27/2012 | Liga MX | L |
Monterrey | 3 - 2 | Santos Laguna | View events | More info |
| 11/02/2012 | Liga MX | W |
Santos Laguna | 2 - 1 | Cruz Azul | View events | More info |
| 11/09/2012 | Liga MX | L |
Morelia | 2 - 0 | Santos Laguna | View events | More info |
| 01/05/2013 | Liga MX | D |
San Luis | 1 - 1 | Santos Laguna | View events | More info |
| 01/11/2013 | Liga MX | W |
Santos Laguna | 2 - 0 | Guadalajara | View events | More info |
| 01/20/2013 | Liga MX | L |
Puebla | 2 - 1 | Santos Laguna | View events | More info |
| 01/25/2013 | Liga MX | W |
Santos Laguna | 2 - 0 | León | View events | More info |
| 02/03/2013 | Liga MX | D |
Pumas | 0 - 0 | Santos Laguna | More info | |
| 02/10/2013 | Liga MX | L |
Santos Laguna | 0 - 1 | Pachuca | View events | More info |
| 02/16/2013 | Liga MX | D |
Tigres UANL | 1 - 1 | Santos Laguna | View events | More info |
| 02/22/2013 | Liga MX | W |
Santos Laguna | 1 - 0 | América | View events | More info |
| 03/01/2013 | Liga MX | W |
Jaguares | 1 - 3 | Santos Laguna | View events | More info |
| 03/05/2013 | Champio… | L |
Houston Dynamo | 1 - 0 | Santos Laguna | View events | More info |
| 03/09/2013 | Liga MX | W |
Santos Laguna | 2 - 1 | Atlante | View events | More info |
| 03/13/2013 | Champio… | W |
Santos Laguna | 3 - 0 | Houston Dynamo | View events | More info |
| 03/16/2013 | Liga MX | W |
Atlas | 1 - 2 | Santos Laguna | View events | More info |
| 03/30/2013 | Liga MX | D |
Santos Laguna | 1 - 1 | Querétaro | View events | More info |
| 04/02/2013 | Champio… | W |
Seattle Sou… | 0 - 1 | Santos Laguna | View events | More info |
| 04/07/2013 | Liga MX | D |
Tijuana | 0 - 0 | Santos Laguna | More info | |
| 04/09/2013 | Champio… | D |
Santos Laguna | 1 - 1 | Seattle Sou… | View events | More info |
| 04/12/2013 | Liga MX | W |
Santos Laguna | 2 - 1 | Toluca | View events | More info |
| 04/19/2013 | Liga MX | W |
Santos Laguna | 1 - 0 | Monterrey | View events | More info |
| 04/24/2013 | Champio… | D |
Santos Laguna | 0 - 0 | Monterrey | View events | More info |
| 04/27/2013 | Liga MX | L |
Cruz Azul | 1 - 0 | Santos Laguna | View events | More info |
| 05/01/2013 | Champio… | L |
Monterrey | 4 - 2 | Santos Laguna | View events | More info |
| 05/04/2013 | Liga MX | L |
Santos Laguna | 1 - 2 | Morelia | View events | More info |
| 05/09/2013 | Liga MX | D |
Santos Laguna | 0 - 0 | Atlas | More info | |
| 05/12/2013 | Liga MX | W |
Atlas | 1 - 3 | Santos Laguna | View events | More info |
| 05/16/2013 | Liga MX | L |
Santos Laguna | 0 - 3 | Cruz Azul | View events | More info |
| 05/19/2013 | Liga MX | Cruz Azul | 9:00 PM EDT | Santos Laguna | More info |